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Insulin-Like Growth Factor I, Recombinant, Human (IGF1, IGF I) (Liquid)

Cat no: I7661-11C

Insulin-Like Growth Factor I, Recombinant, Human (IGF1, IGF I) (Liquid)

Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Recombinant Human IGF-I is a single, nonglycosylated, 7.6kD protein containing 70 amino acid residues. Insulin-like growth factor 1 (IGF-I) is involved in regulation of neuronal growth and development in central and peripheral nervous system. It is known to protect neurons against cell death induced by amyloidogenic derivatives, glucose or serum\ndeprivation through pathways involving AKT kinase and transcription factor FKHRL1 phosphorylation. Activation of the insulin-like growth factor system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like breast and thyroid cancers\n\nBiological Activity: \nHuman IGF-I is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent proliferation of murine BALB/c 3T3 cells (measured by 3H-thymidine uptake) is (same/less than) 1ng/ml, corresponding to a specific activity of 1x10e6 units/mg. For most in vitro applications, IGF1 exerts its biological activity in the concentration range of 0.2-20ng/ml.\n\nResponding Cells (partial list): Bone, muscle cells, CHO cells\n\nAA

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SPECIFICATIONS

Catalog Number

I7661-11C

Size

100ug

Form

Supplied as a lliquid in 50mM acetic acid, 0.1% BSA.. Available as a lyophilized powder, see I7661-11.

Purity

(same/more than) 98% by SDS-PAGE and HPLC analyses. Endotoxin: (same/less than) 0.1ng/ug (1EU/ug)

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