Home  >  Products  >  Insulysin, Recombinant, Rat, 5-His-tag (IDE, insulin-degrading enzyme, FLJ35968, Insulinase, Insulin-degrading Enzyme, Insulin Protease)

Insulysin, Recombinant, Rat, 5-His-tag (IDE, insulin-degrading enzyme, FLJ35968, Insulinase, Insulin-degrading Enzyme, Insulin Protease)

Cat no: I8601-04


Supplier: United States Biological
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Insulysin, or insulin-degrading enzyme (IDE), is a zinc metallopeptidase of the inverzincin family. IDE is primarily located in the cytosol, but has been detected as a secreted enzyme and associated with the plasma membrane as well. The enzyme is expressed in many tissues, with the highest levels in liver, kidney, brain, and testis. IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-a in vitro. In addition, IDE has been shown to degrade the amyloid b (Ab) peptide, which polymerizes into the plaques associated with Alzheimer
Catalogue number: I8601-04
Size: 10ug
Form: Supplied as a liquid in 20mM Tris, 120mM sodium chloride, 0.02% Brij 35, pH 7.0, 20% glycerol
Purity: ~95% (SDS-PAGE) Endotoxin: (same/less than)1EU/1ug (LAL)
References: 1. Affholter, J. A. et al. (1988) Science 242:1415. 2. Duckworth, W. C. et al. (1998) Endocr. Rev. 19:608. 3. Akiyama, H. et al. (1990) Biochem. Biophys. Res. Commun. 170:1325. 4.Selkoe, D. J. et al. (2001) Neuron 32:177. 5. Ghosh, S. et al. (2000) Am. J. Hum. Genet. 67:1174. 6.Farris, W. et al. (2003) Proc. Natl. Acad. Sci. 100:4162.

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