In biopharmaceutical processes, particularly for protein and antibody drugs, charge heterogeneity analysis is crucial for ensuring quality control of bioproducts. Interactions between molecules with different charge can significantly impact the bioactivity, immunogenicity, half-life, and charge stability of drugs, ultimately affecting their efficacy, stability, and safety. Ion chromatography (IC) is a widely recognized technique for analyzing charge heterogeneity in biomolecules by leveraging the char......
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