IQGAP1 Peptide

Cat no: BS5767P

Supplier: Bioworld Technology, Inc.

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IQGAP1, for IQ motif containing GTPase activating protein, is a Ras GAP-related, Actin-binding protein that interacts with the small GTPases Cdc42 and Rac1. The C-terminus of IQGAP1 is essential for interacting with Cdc42 and, in addition, IQGAP1 contains a WW domain and a predicted N-terminal coiled-coil region, which may be involved in IQGAP dimerization. Expression of IQGAP1 is highest in placenta, lung and kidney, where it co-localizes with Cdc42 to the cytoskeleton and assists with Cdc42 in mediating the regulation of cell proliferation, polarity and cell morphology. IQGAP1 regulates cadherin-mediated cell adhesion via binding to E-cadherin, b-catenin and a-catenin. This association induces the accumulation of these proteins at the site of cell-cell contact. IQGAP1 is negatively regulated by calmodulin, which binds to IQGAP1 in a calcium-dependent manner and disrupts IQGAP1 from associating with Cdc42.

Catalogue number:	BS5767P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P46940
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide IQGAP1. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Ras GTPase-activating-like protein IQGAP1; p195; KIAA0051
Additional info:	This peptide can be used with studies using BS5767 IQGAP1 pAb.

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IQGAP1 Peptide

Cat no: BS5767P

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