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IQGAP1 Peptide

Cat no: BS5767P

IQGAP1 Peptide

IQGAP1, for IQ motif containing GTPase activating protein, is a Ras GAP-related, Actin-binding protein that interacts with the small GTPases Cdc42 and Rac1. The C-terminus of IQGAP1 is essential for interacting with Cdc42 and, in addition, IQGAP1 contains a WW domain and a predicted N-terminal coiled-coil region, which may be involved in IQGAP dimerization. Expression of IQGAP1 is highest in placenta, lung and kidney, where it co-localizes with Cdc42 to the cytoskeleton and assists with Cdc42 in mediating the regulation of cell proliferation, polarity and cell morphology. IQGAP1 regulates cadherin-mediated cell adhesion via binding to E-cadherin, b-catenin and a-catenin. This association induces the accumulation of these proteins at the site of cell-cell contact. IQGAP1 is negatively regulated by calmodulin, which binds to IQGAP1 in a calcium-dependent manner and disrupts IQGAP1 from associating with Cdc42.

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SPECIFICATIONS

Catalog Number

BS5767P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide IQGAP1. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P46940

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5767 IQGAP1 pAb.

Alternative Names

Ras GTPase-activating-like protein IQGAP1; p195; KIAA0051

SUPPLIER INFO

Bioworld Technology, Inc.

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