Irisin Polyclonal Antibody

Antigen: human irisin amino acids 1-112 . Host: rabbit . Cross-Reactivity: (+) human; other species not tested . Application(s): ELISA and WB

Prices direct from Cayman Chemical Company

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

14625

Applications

ELISA, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human irisin amino acids 1-112

Storage Temp

-20

Shipping Temp

-20

Additional Info

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1(alpha) (PGC-1(alpha)), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by increased expression of the PGC1-(alpha) protein in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose tissue (WAT) to brown adipose tissue (BAT). An increase in BAT results in anti-obesity and anti-diabetic metabolic states in mice. Exogenous irisin levels in mice leads to higher levels of the uncoupling protein UCP1, which results in an increase in thermogenesis and heat expenditure. The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and metabolic disorder. Cayman's irisin polyclonal antibody detects a 13 kDa band from bacterially expressed irisin protein (Item No. 11451), and a 32 kDa band from deglycosylated human serum.