IRS-4 Antibody

Cat no: 250729

Supplier: ABBIOTEC

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Description
Additional Information

The family of insulin receptor substrates (IRS) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions although the distinct physiological roles of each IRS are unclear. IRS-4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS-4 interacts with cytoplasmic signaling molecules that contain SH2 domains such as IGF1R and FGFR1. IRS-4 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS-4 is involved in the proliferation and differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation.

Catalogue number:	250729
Reactivities:	Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q9Z0Y7
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse IRS-4.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Insulin receptor substrate 4; IRS-4; 160 kDa phosphotyrosine protein; PY160; IRS4