IRS P53 Antibody

Cat no: 250725

Supplier: ABBIOTEC

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Description
Additional Information

Insulin receptor substrate P53 (IRS P53) has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of IRS P53, which is involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. IRS P53 has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.

Catalogue number:	250725
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q9UQB8
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IRS P53.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	IRS P53; Insulin receptor substrate P53; Brain-specific angiogenesis inhibitor 1-associated protein 2; BAI1-associated protein 2; BAI-associated protein 2; BAP2; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53/p58; IRSp53/58; IRS-58; Fas ligand-associated factor 3; FLAF3; BAIAP2