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Isoapoptolidin

Cat no: I9039-95

Isoapoptolidin

Isopoptolidin, originally isolated from a Nocardiopsis sp., is a ring expanded isomer of apoptolidin. In water an equilibrium mixture of apoptolidin/isoapoptolidin (~1.5:1) is formed within hours. In a rapid F0F1-ATPase assay isoapoptolidin exhibited a IC50 of 17 uM compared to 0.7 uM for apoptolidin.\n\nPurity: >90% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO.\n\nRelated to: Apoptolidin

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SPECIFICATIONS

Catalog Number

I9039-95

Size

100ug

Purity

>90% by HPLC

References

1. Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Wender P.A. et al. Org. \nLett. 2002, 4, 3819. \n2. Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of \napoptolidin. Pennington J. D. et al. Org. Lett. 2002, 4, 3823. \n3. Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells. Wender P.A. et al. \nUS Patent Application, 20040180841.

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

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Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

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Applications

ELISA

Hosts

Mouse

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Applications

FC, IP

Hosts

Mouse

Reactivities

Hum

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