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Isoapoptolidin

Cat no: I9039-95


Supplier: United States Biological
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Isopoptolidin, originally isolated from a Nocardiopsis sp., is a ring expanded isomer of apoptolidin. In water an equilibrium mixture of apoptolidin/isoapoptolidin (~1.5:1) is formed within hours. In a rapid F0F1-ATPase assay isoapoptolidin exhibited a IC50 of 17 uM compared to 0.7 uM for apoptolidin. Purity: >90% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Apoptolidin
Catalogue number: I9039-95
Size: 100ug
Purity: >90% by HPLC
References: 1. Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Wender P.A. et al. Org. Lett. 2002, 4, 3819. 2. Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin. Pennington J. D. et al. Org. Lett. 2002, 4, 3823. 3. Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells. Wender P.A. et al. US Patent Application, 20040180841.

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