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Isoniazid

Isoniazid

Cat no: 015047

Supplier: United States Biological
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Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). Form: White Solid Melting Point: 167-169 degrees C Solubility: DMSO, Methanol
Catalogue number: 015047
Size: 1g
Form: White Solid
Alternative names: 4-Pyridinecarboxylic Acid Hydrazide; Isonicotinic Acid Hydrazide; 4-(Hydrazinocarbonyl)pyridine; 4-Pyridinecarbonylhydrazine; 4-Pyridinecarboxylic Hydrazide; 4-Pyridylcarbonylhydrazide; 5015 R.P.; Armazid; Armazide; Atcotibine; Isonizide; Isotebezid; Isozide; Robisellin; Sauterazid; Zinadon; Zonazide; Tubazid;
References: Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

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