logo
logo
Isradipine

Cat no: I-100

Isradipine

Isradipine. A Potent Blocker ofпїЅL-type (Cav1.2 and Cav1.3)пїЅCa2+ Channels.

L-type (Cav1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle where they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
Isradipine is a dihydropyridine that acts as a L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension.
Isradipine inhibits L-type channels expressed in Xenopus oocytes with IC50 = 0.2 μM at a holding potential of -80 mV and the inhibition is state dependent and increases with reduced membrane hyperpolarization. Slow excitatory synaptic currents in dopaminergic neurons in slices of rat substantia nigra pars compacta and ventral tegmental area, which were evoked by a train of focally delivered electrical stimuli, were depressed by isradipine (30 nM-100 μM) in a concentration-dependent and reversible manner.
In addition, isradipine, was shown recently to be a putative effective treatment for ParkinsonпїЅs disease, by affecting particularly the excitability of certain Cav1.3 expressing dopaminergic neurons.
In a pancreatic cell line, insulin secretion triggered by 16.7 mM glucose, was completely abolished by 5 μM isradipine.

Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.

Prices direct from Alomone Labs Ltd.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

I-100

Size

5 mg

Purity

>99%

Concentration

50 nM - 5 uM

Shipping Temp

Room Temperature

Molecular Weight

371.4 da

Latest promotions

Spend less time on DNA cleanup so you can do more science. The MSB Spin PCRapace is the fastest way to purify your DNA from PCR, restriction digestion, and...

Genovis introduces GlycINATOR™• Works on most IgGs• Effective on high-mannose and bisected N-linked Fc-glycans • Rapid – 30-minute...

Use promo code EASY3 to receive 13% off and FREE shipping!Experience a new dimension of electronic pipetting with the NEW Easypet 3 pipette controller. The...

New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...

As an incentive to qualify our BSA, we are offering a 20% discount when you purchase your first 100g, 500g or 1000g of any grade of Bovine Serum Albumin....

It is not every day that you are given something for nothing. We are giving away additional spectrophotometer software.Cecil Instruments have enhanced the...

We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!

For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...

10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...

Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...

Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...

Jenway’s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of –0.3 to 2.5A,...

Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...