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ITGB3, phosphorylated (Tyr773) (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, CD61, GP3A)

Cat no: I7661-42K1

ITGB3, phosphorylated (Tyr773) (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, CD61, GP3A)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. AlphaIIbeta3 and alphaVbeta3 are the two beta3 containing integrins, which are prominently expressed in hematopoitic cells and angiogenic endothelic cells and perform adhesive functions in hemostasis, wound healing and angiogenesis. Integrin b3 localizes in the 17q21.32 region of chromosome. Alternate splicing of integrin b3 produces three isoforms, Beta-3A, Beta-3B and Beta-3C. Isoform beta-3A is specifically expressed in osteoblast cells and isoform beta-3C is specifically expressed in prostate and testis. Defects in integrin b3 cause Glanzmann thrombasthenia (GT).\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I7661-42K1

Size

50ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human ITGB3, phosphorylated at Tyr773. Species Crossreactivity: mouse.

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