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Ivermectin (Dihydroavermectin B1a, Ivermectin B1a, 22, 23-Dihydro-avermectin B1a )

Cat no: D3570-04

Ivermectin (Dihydroavermectin B1a, Ivermectin B1a, 22, 23-Dihydro-avermectin B1a )

Ivermectin B1a is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.\n\nSoluble in ethanol, methanol, DMF or DMSO.

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SPECIFICATIONS

Catalog Number

D3570-04

Size

1mg

Form

White solid

Purity

>95% by HPLC

References

1. Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134. 2. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J & Rogers A.T. Parasitology, 2005, 131, S85. 3. Avermectin/milbemycin resistance in trichostrongylid nematodes. Gill J.H. & Lacey E. Int J. Parasitol. 1998, 28, 863. 4. Ivermectin: a potent new antiparasitic agent. Campbell W.C. et al., Science, 1983, 221, 823.

Alternative Names

Ivermectin, Ivermectin B1a, 22, 23-Dihydro-avermectin B1a

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