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Jagged-1, Recombinant, Mouse:Fc (Protein Jagged-1, CD339, JAG1)

Cat no: 044969

Jagged-1, Recombinant, Mouse:Fc (Protein Jagged-1, CD339, JAG1)

Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).\n\nBiological Activity:\nInhibits adipogenesis of 3T3L-1 cells\n\nSequence:\nSignal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

044969

Size

10ug

Form

Supplied as a liquid in PBS, pH 7.2.

Purity

(same/more than)90% (SDS-PAGE). Endotoxin: (same/less than)0.1EUug (LAL)

Alternative Names

Protein Jagged-1, CD339, JAG1

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