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Jagged-2:Fc, Recombinant, Human (Protein Jagged-2, hJ2, JAG2)

Jagged-2:Fc, Recombinant, Human (Protein Jagged-2, hJ2, JAG2)

Cat no: 044972

Supplier: United States Biological
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Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. Sequence: Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 044972
Size: 10ug
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: Protein Jagged-2, hJ2, JAG2

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