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JAK2, Control Peptide (Janus Kinase 2)

Cat no: J0901-03A

JAK2, Control Peptide (Janus Kinase 2)

The Janus (JAK) family of cytoplasmic tyrosine kinases has been implicated in signal transduction induced by cytokines and growth factors, physically associated with ligand-bound receptors. This association that results in tyrosine phosphorylation and activation. JAK1 is approximately 130kD and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among JAK family members. Family members such as JAK1, JAK2, and TYK2 are ubiquitous, whereas JAK3 is predominantly expressed in T lymphocytes. Studies with mutant cells that do not express JAK1, JAK2, or TYK2 show that their activation is essential for cellular signaling. JAK family kinases may either phosphorylate each other or be phosphorylated by a yet undescribed tyrosine kinase. Different cytokines can activate via phosphorylation distinct JAK family members. In some cells, the membrane-associated gp130 protein has been implicated in the induction of JAK family phosphorylation, although gp130 itself has no known activity.\n\nControl peptide for JAK 2 rabbit polyclonal antibody.\nSequence (linear): Ac-Asp-Ser-Gln-Arg-Lys-Leu-Gln-Phe-Tyr-Glu-Asp-Lys-His-Gln-Leu-Pro-Ala-Cys-\n\nNH2Amino Acid Analysis and Identity:\nConfirms expected sequence\n\nPeptide Content: 81.9

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SPECIFICATIONS

Catalog Number

J0901-03A

Size

1mg

Form

Supplied as a lyophilized powder.

Purity

~90% by HPLC and MS analysis

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