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JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine)

JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine)

Cat no: J1299-25

Supplier: United States Biological
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An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Catalogue number: J1299-25
Size: 1mg
Form: Supplied as a beige solid. Reconstitute with 100mM DMSO and 25mM ethanol.
Purity: ~98% (HPLC)
Alternative names: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
References: 01., T., et al. (2009). Angew. Chem. Int. Ed.Engl. 48, 2321-2324; 2. Lee, J., et al. (2007). Chembiochem 8, 1916- 1919.

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