JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II)

Cat no: 029523

Supplier: United States Biological

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A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Solubility: DMSO (15mg/ml). For every 10uM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility. Molecular Weight: ~220.2 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	029523
Size:	5mg
Form:	Supplied as a yellowish orange solid.
Purity:	(same/more than)98% by HPLC
References:	1. Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311. 2. Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. 3. Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

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JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II)

Cat no: 029523

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