K-252a (SF 2370, Antibiotic K 252a, Antibiotic SF 2370)

Size

100ug

References

Product Reference: \n?K-252a, a potent inhibitor of protein kinase C from microbial origin: H. Kase, et al.; J. Antibiot. (Tokyo) 39, 1059 (1986)\n?K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases: H. Kase, et al.; BBRC 142, 436 (1987)\n?K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells: s. Koizumi, et al.; J. Neurosci. 8, 715 (1988)\n?Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases: U.T. Ruegg & G.M. Burgess; TIPS 10, 218 (1989) (Review)\n?K252a is a potent and selective inhibitor of phosphorylase kinase: L.H. Elliott, et al.; BBRC 171, 148 (1990)\n?Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926: Y. Hashimoto, et al.; BBRC 181, 423 (1991)\n?K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors: P. Tapley, et al.; Oncogene 7, 371 (1992)\n?Specific inhibition of NGF receptor tyrosine kinase activity by K-252a: K. Muroya, et al.; Biochim. Biophys. Acta 1135, 353 (1992)\n?K252a: a new blocker of the cell-cycle at G1 phase in a human hepatoma cell line: T. Nakayama, et al.; Experientia 49, 876 (1993)\n?Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines: R. Delsite & D. Djakiew; J. Androl. 17, 481 (1996)\n?K252a and staurosporine microbial alkaloid toxins as prototype of neurotropic drugs: P. Lazarovici, et al.; Adv. Exp. Med. Biol. 391, 367 (1996) (Review)\n?K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c: L.S. Chin, et al.; Cancer Invest. 17, 391 (1999)\n?K252a inhibits the oncogenic properties of Met, the HGF receptor: A. Morotti, et al.; Oncogene 21, 4885 (2002)\n?K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model: S.P. Raychaudhuri, et al.; J. Invest. Dermatol. 122, 812 (2004)\n?K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1: N. Takai, et al.; Oncol. Rep. 14, 141 (2005)\n?K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion: Q. Wang, et al.; J. Recept. Signal. Transduct. Res. 31, 307 (2011)\n?