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K252a (2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-(9S,10R,12R)-9,12-epoxy-1H-diindolo[1,2,3-fg:3

Cat no: K0000-50D

K252a (2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-(9S,10R,12R)-9,12-epoxy-1H-diindolo[1,2,3-fg:3

K252a is a kinase inhibitor that inhibits PKA (Ki=18nM), PKC (Ki=25nM), and PKG (Ki=20nM).\n\nSolubility:\nSoluble in DMSO at 100mg/ml; poorly soluble in ethanol.\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

K0000-50D

Size

1mg

Form

Supplied as an off-white powder.

Purity

~99%

References

1. Kase, H., et al. \"K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.\" Biochem. Biophys. Res. Commun. 142:436-440 (1987). 2. Hashimoto, Y., et al. \"Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926.\" Biochem. Biophys. Res. Commun. 181:423-429 (1991). 3. Elliott, L.H., et al. \"K252a is a potent and selective inhibitor of phosphorylase kinase.\" Biochem. Biophys. Res. Commun. 171:148-154 (1990). 4. Berg, M.M., et al. \"K-252a Inhibits Nerve Growth Factor-induced trk Proto-oncogene Tyrosine Phosphorylation and Kinase Activity.\" J. Biol. Chem. 267:13-16 (1992). 5. Lloyd, E.D. and Wooten, M.W. \"pp42/44MAP kinase is a component of the neurogenic pathway utilized by nerve growth factor in PC12 cells.\" J. Neurochem. 59:1099-1109 (1992). 6. Mohri, T., et al. \"K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c.\" Cancer Invest. 17:391-395 (1999).

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