

Supplier:
Alomone Labs Ltd.Cat no: K-150
K252a
K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This ATP analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50= 1.8 and 1.7 nM respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50пїЅof 10 to 30 nM).
It is reported to promote myogenic differentiation in C2 mouse myoblasts and has been shown to block the neuronal differentiation of rat pheochromocytoma PC12 cells by inhibition of trk tyrosine kinase activity. Paradoxically K252a exerts neurotrophic effects on primary sensory neurons, neuroblastoma cells, PC12 cells, and central neuron.
Protein Kinase Inhibitors and Activatiors; Protein Kinase Inhibitors (non specific)
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SPECIFICATIONS
Catalog Number
K-150
Size
5 x 50 micro g
Purity
>98%
Concentration
10-200 nM.
Shipping Temp
Room Temperature
Molecular Weight
467
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