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K252a

Cat no: K0000-50A

K252a

K252a is an alkaloid isolated from Nocardiopsis sp. soil fungi. This compound is a highly potent cell permeable CaM Kinase II inhibitor (IC50=1.8nM). At higher concentrations it also inhibits broad spectrum of protein kinases (1

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SPECIFICATIONS

Catalog Number

K0000-50A

Size

100ug

Form

Supplied as a lyophilized powder. Not sterile.

Purity

~98%

References

1. Kase, H., et al. (1987) Biophys. Res. Commun. 142(2):436-440. 2. Yamada, K., et al. (1987) Biochem. Biophys. Res. Commun. 144(1):35-40. 3. Yamada, M., et al. (1997) J. Biol. Chem. 272(48):30334-30339. 4. Dickens, G., et al. (1997) J. Neurosci. Res. 47(3):271-276. 5. Angeles, T.S., S.X. Yang, C. Steffler, and C.A Dionne (1998) Arch. Biochem. Biophys. 349(2):267-274. 6. McLaughlin, J.P. and C. Chavkin (2001) Mol. Pharmacol. 59(6):1360-1368.

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