Karyopherin alpha 2 (KPNA2, Importin alpha 1, Pendulin, RAG Cohort 1) Recombinant, Human

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. \n\nSpecies: Homo sapiens\n\nSource: E. coli\n\nPrimary Sequence (aa): 529\n\nDomain (aa): Full-length\n\nTag/Fusion Partner: T7 Tag\n\nApplications: Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested.\n\nQuality Control: SDS-PAGE Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. \n\nImportant note: This recombinant enzyme has NOT been tested with regard to biological activity.

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