Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of Leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumour activity both in vitro and in vivo against P388 and L1210 cell lines and also shows strong antibacterial and antifungal activity.
Purity: >95% by HPLC
Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.
Related to: Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin B,