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Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 )

Cat no: K0108-85A

Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 )

Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.\n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.\n\nRelated to: Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin A

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SPECIFICATIONS

Catalog Number

K0108-85A

Size

100ug

Purity

>95% by HPLC\n

References

1. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the \nhuman immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Wolff B. et al. \nChem. Biol. 1997, 4, 139. \n2. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. Takamiya K. \net al. J. Antibiot. 1988, 41, 1854. \n3. PD 124,895 and PD 124,966, two new antitumor antibiotics. Hurley T.R. et al. J. Antibiot. 1986, 39, \n1651.

Alternative Names

Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895

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