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Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 )

Cat no: K0108-85A


Supplier: United States Biological
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Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity. Purity: >95% by HPLC Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO. Related to: Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin A
Catalogue number: K0108-85A
Size: 100ug
Purity: >95% by HPLC
Alternative names: Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895
References: 1. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Wolff B. et al. Chem. Biol. 1997, 4, 139. 2. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. Takamiya K. et al. J. Antibiot. 1988, 41, 1854. 3. PD 124,895 and PD 124,966, two new antitumor antibiotics. Hurley T.R. et al. J. Antibiot. 1986, 39, 1651.

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