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KC7F2 (N,N'-(Dithiodi-2,1-ethanediyl)bis[2, 5-dichlorobenzenesulfonamide)

Cat no: 145680

KC7F2 (N,N'-(Dithiodi-2,1-ethanediyl)bis[2, 5-dichlorobenzenesulfonamide)

Inhibitor of HIF-1alpha. Thought to act via down-regulation of HIF-1alpha protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1alpha accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.\n\nSequence:\nC16H16Cl4N2O4S4\n\nSolubility:\nDMSO (~100mM)\n\nMolecular Weight:\n~570.38\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

145680

Size

10mg

Form

Supplied as a white solid.

Purity

~98% (HPLC)

References

1. Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin. Cancer Res. 15:5945. PMID: 19789327. 2. Narita et al (2009) Identification of a novel small molecule HIF-1a translation inhibitor. Clin.Cancer Res. 15: 6128. PMID: 19789328.

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