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Keratin 10, CT (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KPP)

Keratin 10, CT (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KPP)

Cat no: C9097-10E

Supplier: United States Biological
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Cytokeratin 10 (CK10) belongs to a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non- keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. CK10 is expressed in all suprabasal layers of the epidermis. It is absent in the basal layer, but appears in the first suprabasal layers and increases in concentration towards the granular layer. Expression of CK10 is related to maturation of malignant keratinocytes, preferentially detected in more-differentiated parts. CK10 is also associated with human hepatocellular carcinoma (HCC) invasiveness. CK10 alone, or in combination with CK19, can be a novel predictor for poor prognosis of HCC patients after curative resection. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9097-10E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH7.4, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Van der Velden, L.A. et al. (1993) Head Neck 15: 133-146. 2. Ivanyi D et al. Differentiation. (1989) Dec; 42 (2) 124-9. 3. Yang, XR et al. Clin Cancer Res. (2008) Jun 15; 14 (12) 3850-9.
Additional info: Recognizes human Keratin-10.

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