Keratin 19 (Keratin Type I Cytoskeletal 19, Keratin-19, K19, KRT19, Cytokeratin 19, Cytokeratin-19, CK 19, CK19, CK-19, K1CS, MGC15366)

Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. Cytokeratin 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. It is unique in that it has a very short 13-amino acid tail domain. It possesses assembly properties and it may impart unique properties to the basal cells expressing it in skin epithelia. It maps to the 17q21.2 region oh Human chromosome and has a molecular weight of 44,098 Da. It is expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nSkin\n\nCellular Localization: \nCytoplasmic\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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