KIR2DL1, Recombinant, Human (p58 KIR, p58.1, CD158, cl-42, KIR-K6, NKAT1, NKR-K6, Killer Cell Immunoglobulin (Ig)-like Receptor)

An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The extracellular domain of KIR2DL1 was over expressed as insoluble protein aggregates(inclusion bodies) Recombinant KIR2DL1 produced in E.Coli is a single,non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2kD.\n\nSequence: \nMEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN\n\nStability: \nStore at 4 degrees C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degrees C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

K1858-40A

Size

5ug

Form

Supplied as a liquid in 25mM Tris-HCl, pH 7.5.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Reduced KIR2DL1 recognition of MHC class I molecules presenting phosphorylated peptides.\n\nJ Immunol 2006 Jun 1;176(11):6762-9\n\n2. Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation.\n\nBr J Haematol 2005 Nov;131(4):483-6\n\n3. Expression of inhibitory-motif killer immunoglobulin-like receptor, KIR2DL1, is increased in natural killer cells from women with pelvic endometriosis.\n\nAm J Reprod Immunol 2005 May;53(5):249-54\n\n4. [Expression of human KIR2DL1-Ig fusion protein in COS-7 cells]\n\nXi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2003 May;19(3):245-7\n\n5. Expression of KIR2DL1 on the entire NK cell population: a possible novel immunodeficiency syndrome.\n\nBlood 2004 Mar 1;103(5):1965-6\n\n6. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis.\n\nFertil Steril 2002 Feb;77(2):297-302