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KIR2DL3, Recombinant, Human (p58 KIR, CD158, cl-6, KIR-K7, NKAT2, NKR-K7, Killer Cell Immunoglobulin (Ig)-like Receptor)

Cat no: K1858-46A

KIR2DL3, Recombinant, Human (p58 KIR, CD158, cl-6, KIR-K7, NKAT2, NKR-K7, Killer Cell Immunoglobulin (Ig)-like Receptor)

An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, cl-6, NKAT2 or KIR-K7), which recognizes class I MHC molecules(HLA-Cw1, -Cw3, -Cw7, and Cw8). Recombinant KIR2DL3 produced in E.Coli is a single,non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22kD.\n\nSequence: \nMEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGIS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GN\n\nStability: \nStore at 4 degrees C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degrees C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

K1858-46A

Size

5ug

Form

Supplied as a liquid in 25mM Tris-HCl, pH 7.5.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.\n\nInt Immunol 2004 Oct;16(10):1459-66\n\n2. Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3.\n\nTissue Antigens 2004 Aug;64(2):188-94\n\n3. Modulation of T-cell functions in KIR2DL3 (CD158b) transgenic mice.\n\nBlood 199 9 Oct 1;94(7):2396-402\n\n4. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.\n\nStructure 1999 Apr 15;7(4):391-8

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