KIR3.4 Peptide

Cat no: BS5775P

Supplier: Bioworld Technology, Inc.

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G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, Kir3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbg subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gb3- and Gb4-containing Gbg dimers bind directly to cytoplasmic domains of Kir3 proteins and increase the K+ current while Gb5-containing Gbg dimers inhibit Kir3 K+ current. Kir3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates Kir3 tyrosine residues, effectively inactivating the Kir3 channels.

Catalogue number:	BS5775P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P48544
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide KIR3.4. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	G protein-activated inward rectifier potassium channel 4; GIRK-4; GIRK4; Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; IRK4; KATP1; Potassium channel, inwardly rectifying subfamily J member 5; KCNJ5;
Additional info:	This peptide can be used with studies using BS5775 KIR3.4 pAb.

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KIR3.4 Peptide

Cat no: BS5775P

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