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KLK1, Recombinant, Human, aa25-262, His-Tag (Kallikrein-1, hK1, Klk6, KLKR)

Cat no: 138677

KLK1, Recombinant, Human, aa25-262, His-Tag (Kallikrein-1, hK1, Klk6, KLKR)

Kallikrein-1, also known as KLK1, belongs to the Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. \n\nSource:\nRecombinant protein corresponding to aa25-262 from human KLK1 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~28.7kD (259aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH M ESFPHPGFNM SLLENHTRQA DEDYSHDLML LRLTEPADTI TDAVKVVELP TQEPEVGSTC LASGWGSIEP ENFSFPDDLQ CVDLKILPND IVGGWECEQ HSQPWQAALY HFSTFQCGGI LVHRQWVLTA AHCISDNYQL WLGRHNLFDD ENTAQFVHVS\nECKKVHVQKV TDFMLCVGHL EGGKDTCVGD SGGPLMCDGV LQGVTSWGYV PCGTPNKPSV AVRVLSYVKW IEDTIAENS\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138677

Size

20ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.15M sodium chloride,1mM DTT,10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Lu H.S., et al. (1989) Int. J. Pept. Protein Res. 33:237-249 2. Kellermann J., et al. (1988) Protein Seq. Data Anal. 1:177-182.

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