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KLK7, Recombinant, Human, aa30-253, His-Tag (Kallikrein-7, hK7, PRSS6, SCCE)

Cat no: 138678

KLK7, Recombinant, Human, aa30-253, His-Tag (Kallikrein-7, hK7, PRSS6, SCCE)

KLK7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikreins are biomarkers for cancer. The protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. KLK7 may play a role in cancer invasion and metastasis, and increased expression of this protein is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. \n\nSource:\nRecombinant protein corresponding to aa30-253 from human KLK7 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~27.1kD (249aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSHM ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL IIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIKENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDPGV YTQVCKFTKW INDTMKKHR\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138678

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 2M urea, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Talieri,M.,et al. (2011) Anticancer Res. 31(9), 3093-3100 2. Ramani,V.C., et al. (2011) Biochim. Biophys. Acta 1813(8), 1525-1531.

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