KMT1B (H150) pAb

SUV39H2 (suppressor of variegation 3-9 homolog 2), also known as KMT1B or Histone H3-K9 methyltransferase 2, is a 410 amino acid protein that localizes to the centromere and contains one SET domain, one pre-SET domain, one post-SET domain and one chromo domain. Expressed at high levels in adult testis, SUV39H2 functions as a histone methyltransferase that trimethylates the Lys-9 residue of Histone H3, thereby playing an essential role in establishing constitutive heterochromatin at pericentric and telomere regions. SUV39H2 conveys its enzymatic activity via its multiple catalytic domains, which are necessary for both stable binding of SUV39H2 to chromatin and for SUV39H2 methyltransferase activity. Multiple isoforms of SUV39H2 exist due to alternative splicing events.

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SPECIFICATIONS

Catalog Number

BS2900

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 118-168 of Human KMT1B.

Species

KMT1B (H150) pAb detects endogenous levels of KMT1B protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q9H5I1

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 46 kDa

Alternative Names

FLJ23414; \nH3 K9 HMTase 2; \nH3-K9-HMTase 2; \nHistone H3 K9 methyltransferase 2; \nHistone H3-K9 methyltransferase 2; \nHistone lysine N methyltransferase H3 lysine 9 specific 2; \nHistone lysine N methyltransferase SUV39H2; \nHistone-lysine N-methyltransferase SUV39H2; \nKMT1B; \nLysine N methyltransferase 1B; \nLysine N-methyltransferase 1B; \nsSuppressor of variegation 3 9 homolog 2 (Drosophila); \nSu(var)3 9 homolog 2; \nSu(var)3-9 homolog 2; \nSuppressor of variegation 3 9 homolog 2; \nSu