Ku, p70, p80, Recombinant, Human

Ku antigen consists of two polypeptides (70kD and 80kD; the p80 subunit is occasionally called p86). The Ku heterodimer provides DNA-binding and regulatory functions to DNA-dependent protein kinase which is a central enzyme for DNA recombination processes in eucaryotic cells. The Ku protein plays important roles in multiple nuclear processes including DNA repair, V(D)J recombination, telomere maintenance, and the regulation of specific gene transcription. Antibodies to Ku were originally reported in scleroderma-polymyositis overlap syndrome (up to 20% of patients) but have also been detectable in about 20 % of patients with primary pulmonary hypertension (as a complication of overlap), in 5-10 % of SLE and MCTD patients, and in up to 20 % of patients with primary Sj

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

K7965-05H

Size

5ug

Form

Supplied as a liquid in 16mM HEPES buffer, pH 8.0, 250mM sodium chloride and 20% glycerol.

Purity

(same/more than) 90% (SDS-PAGE)

References

1. Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells.\n\nRetrovirology 2005 Jul 13;2(1):45\n\n2. Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.\n\nMol Cancer Ther 2005 Apr;4(4):529-36\n\n3. The Ku protein complex is involved in length regulation of Drosophila telomeres.\n\nGenetics 2005 May;170(1):221-35\n\n4. The double life of the Ku protein: facing the DNA breaks and the extracellular environment.\n\nCell Cycle 2005 Mar;4(3):438-41\n\n5. Association between autoantibodies to the Ku protein and DPB1*.\n\nArthritis Rheum 2005 Feb;52(2):668-9\n\n6. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.\n\nMol Cell Biol 2004 Oct;24(19):8705-15