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Lactacystin

Cat no: L0900-02


Supplier: United States Biological
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Cell-permeable. A potent and selective inhibitor of the 20S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic beta-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin- like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC50 = 10uM). Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: L0900-02
Size: 200ug
Form: Supplied as a white solid. Reconstitute with DMSO to 25mg/ml or sterile ddH2O to 5mg/ml.
Purity: ~95% (HPLC).
References: 1. Fenteany, G., et al. (1995). Science 268, 726-731.

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