LAG-3:Fc, Recombinant, Human (Lymphocyte Activation Gene-3, FDC Protein, CD223)

Lymphocyte activation gene 3 (LAG-3) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.\n\nSequence:\nThe sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.\n\nEndotoxin (LAL):\n(same/less than)0.1EU/ug\n\nBiological Activity:\nInhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

044993

Size

50ug

Form

Supplied as a liquid in PBS.

Purity

(same/more than) 99% (SDS-PAGE)

References

1. Huard, B., et al., Eur. J. Immunol. 25: 2718 (1995). 2. Huard, B., et al., Eur. J. Immunol. 26: 1180 (1996). 3. Andreae, S., et al., J. Immunol. 168: 3874 (2002). 4. Buisson, S. & Triebel, F., Immunology 114: 369 (2005). 5. Triebel, F., et al., Cancer Lett. 235: 147 (2006). 6. Brignone, C., et al., J. Immunol. 179: 4202 (2007).

Additional Info

Binds to human, mouse and monkey MHC class II.

Alternative Names

Lymphocyte Activation Gene-3, FDC Protein, CD223