LDLR Antibody

Cat no: 250514

Supplier: ABBIOTEC

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Description
Additional Information

The Low-density lipoprotein receptor (LDLR) binds LDL, the major cholesterol-carrying lipoprotein of plasma, on the cell surface in clathrin-coated pits, followed by endocytosis. LDLR defects lead to familial hypercholesterolemia (FH), a common autosomal semi-dominant disease affecting 1 in 500 individuals and characterized by cholesterol deposit in the skin, tendons, and coronary arteries (atherosclerosis). LDLR acts as a receptor for the HIV-1 Tat protein in neurons and mediates its internalization.

Catalogue number:	250514
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P01130
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human LDLR.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	Low-density lipoprotein receptor; LDL-R; Low-density lipoprotein receptor precursor; LDL receptor; LDLR