Home  >  Products  >  LDN 57444, UCH-L1 Inhibitor (5-Chloro-1-[(2,5-dichlorophenyl)met hyl]-1H-indole-2,3-dione 3-(O-acetyloxime))

LDN 57444, UCH-L1 Inhibitor (5-Chloro-1-[(2,5-dichlorophenyl)met hyl]-1H-indole-2,3-dione 3-(O-acetyloxime))

Cat no: L1585-25A


Supplier: United States Biological
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Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4uM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Sequence: 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione Molecular Weight: ~397.64 Solubility: DMSO (~20mg/ml) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: L1585-25A
Size: 5mg
Form: Supplied as a yellow solid.
Purity: ~98% (TLC)

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