Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4uM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Sequence:
3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione
Molecular Weight:
~397.64
Solubility:
DMSO (~20mg/ml)
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Quick Search
Products ![LDN 57444, UCH-L1 Inhibitor (5-Chloro-1-[(2,5-dichlorophenyl)met
hyl]-1H-indole-2,3-dione 3-(O-acetyloxime))](/system/suppliers/default_product_images/000/000/160/main/US-Biological-Life-Sciences.jpg?1386100414)
