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LEAF(TM) Purified anti-human CD273 (B7-DC, PD-L2)

LEAF(TM) Purified anti-human CD273 (B7-DC, PD-L2)

Cat no: 345504

Supplier: BioLegend
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CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions. Clone MIH18 is reported to block PDL2.
Catalogue number: 345504
Reactivities: Human
Hosts: Mouse
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 500 microg
Clone: MIH18
Gene: 80380
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?2.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: Human B7-DC transfected cells
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: B7DC, PDL2
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