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LEAF(TM) Purified anti-human FcepsilonRIalpha

LEAF(TM) Purified anti-human FcepsilonRIalpha

Cat no: 334604

Supplier: BioLegend
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High affinity IgE receptor (FcepsilonRI) plays a key role in IgE-mediated allergic immune response. FcepsilonRI is a tetrameric receptor complex, which is composed of one alpha-subunit (FcepsilonRIalpha), one beta-subunit, and two gamma-subunits. FcepsilonRIalpha directlybinds IgE with high affinity, while the beta- and gamma-chains are responsible for mediatingintracellular signals. FcepsilonRIalpha is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcepsilonRIalpha is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.
Catalogue number: 334604
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 200 microg
Clone: AER-37 (CRA-1)
Gene: 2205
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume or 100 microl of whole blood . It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: FceRIa, FceRI-a, FceRI-alpha, FceRI alpha, high affinity IgE receptor
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