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LEAF(TM) Purified anti-human Integrin alpha9beta1

LEAF(TM) Purified anti-human Integrin alpha9beta1

Cat no: 351603

Supplier: BioLegend
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Integrin alpha9beta1 is a transmembrane protein belonging to the integrin family. It is widely expressed in airway epithelium, different types of muscle cells, and hepatocytes. In the hematopoietic system, integrin alpha9beta1 is highly expressed on human neutrophils and at low level on monocytes. Multiple ligands have been identified for this integrin including the inducible endothelial counter-receptor, vascular cell adhesion molecule-1 (VCAM-1), the extracellular matrix proteins tenascin C and osteopontin, some members of ADAMs family, coagulation factor XIII, and von Willebrand factor. It has been reported that binding of the alpha9 cytoplasmic domain to spermidine/spermine N(1)-acetyltransferase (SSAT) mediates alpha9beta1 enhancement of cell migration, mediates adhesion to the extracellular matrix proteins, and is involved in G-CSF signaling. More recently, integrin alpha9beta1 was found on hematopoietic stem and progenitor cells to mediate stem cells adhesion, proliferation, and differentiation.
Catalogue number: 351603
Reactivities: Human
Hosts: Mouse
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunofluorescence, Immunoprecipitation
Size: 50 microg
Clone: Y9A2
Gene: 3680,3688
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: L-cells transfected with human alpha9
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
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