LEAF(TM) Purified anti-Human/Mouse/Rat CD278 (ICOS)

Cat no: 313511

Supplier: BioLegend

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Description
Additional Information

ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

Catalogue number:	313511
Reactivities:	Human, Mouse, Rat
Hosts:	Hamster
Applications:	Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size:	50 microg
Clone:	C398.4A
Gene:	100048841,29851,64545
Dilutions:	For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that reagents be titrated for optimal performance in the particular application. The LEAFTM (low endotoxin, azide-free) format is recommended for functional assays.
Storage buffer:	The antibody solution should be stored undiluted at 4C.This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	Mouse T cell clone D10.G4.1
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Inducible COStimulatory molecule, H4