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LEAF(TM) purified anti-human TL1A

LEAF(TM) purified anti-human TL1A

Cat no: 322204

Supplier: BioLegend
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TL1A, also known as TNF ligand-related molecule 1, vascular endothelial growth inhibitor, and TNF ligand superfamily member 15, is a type II membrane protein with a predicted molecular weight of 28 kD. TL1A can also be found as a secreted protein as a result of proteolytic cleavage, with a reported molecular weight of 32 kD. TL1A is a ligand for DR3 and DcR3 and is highly expressed in endothelial cells. TL1A expression has also been observed in kidney, lung, prostate, placenta, and liver. Expression of TL1A is inducible with TNF and IL-1alpha (but not IFN-gamma). TL1A acts to inhibit endothelial cell growth and has been reported to induce endothelial cell apoptosis and inhibit neovascularization in tumors. In lymphocytes, TL1A has been shown to enhance IL-2 receptor alpha and beta expression and increase IL-2 induced proliferation and secretion of IFN-gamma and GM-CSF. The 6E6 monoclonal antibody recognizes human TL1A and has been shown to be useful for immunoprecipitation and Western blot. In addition, the 6E6 antibody has been reported to enhance endothelial cell proliferation, motility and migration, and induce the formation of tube networks.
Catalogue number: 322204
Reactivities: Human
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 500 microg
Clone: 6E6
Gene: 9966
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: TL1A peptide (AQGEACVQFQALKGQEFAPS)
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNF ligand superfamily member 15, TNF ligand-related molecule 1
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