LEAF(TM) Purified anti-mouse CD120a (TNFRI/p55)

Cat no: 112902

Supplier: BioLegend

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CD120a is a 55 kD Type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type I (TNFRI) or p55. It is expressed on a variety of cells at low levels. Resting T cells and erythrocytes express very little to no CD120a. This receptor binds both TNF-alpha and LT-alpha (also known as TNF-beta). In association with TRADD and RIP, the receptor crosslinking induced by TNF-alpha or LT-alpha trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The 55R-170 antibody has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.

Catalogue number:	112902
Reactivities:	Mouse
Hosts:	Hamster
Applications:	Block/Neutralize/Inhibit, Flow Cytometry, Immunoprecipitation
Size:	500 microg
Clone:	55R-170
Gene:	21937
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	E. coli-expressed extracellular domain of the mouse TNFRI protein
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	TNFR type I, TNFRI, TNFR60, p55, TNFRSF1A

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LEAF(TM) Purified anti-mouse CD120a (TNFRI/p55)

Cat no: 112902

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