Home  >  Products  >  LEAF(TM) purified anti-mouse CD120b (TNFRII/p75)
LEAF(TM) purified anti-mouse CD120b (TNFRII/p75)

LEAF(TM) purified anti-mouse CD120b (TNFRII/p75)

Cat no: 113202


Supplier: BioLegend
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-alpha and LT-alpha (also known as TNF-beta). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-alpha or LT-alpha trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-32.4 antibody has been shown to block ligand-induced receptor signaling.
Catalogue number: 113202
Reactivities: Mouse
Hosts: Hamster
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunoprecipitation
Size: 500 microg
Clone: TR75-32.4
Gene: 21938
Dilutions: Each lot of this antibody is quality control tested by ELISA and/or immunofluorescent staining with flow cytometric analysis. For ELISA detection applications, a concentration range of 0.125-0.5 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of TNF R Type II/p75 recombinant protein ranging from 250 to 4 pg/ml are recommended for each ELISA plate. For immunofluorescent staining, the suggested use of this reagent is ? 0.5 microg per 106 cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: E. coli -expressed mouse Type II TNFR
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNFRII, TNFR type II, p75, TNFR80, TNFRSF1B
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave