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LEAF(TM) purified anti-mouse CD120b (TNFRII/p75)

LEAF(TM) purified anti-mouse CD120b (TNFRII/p75)

Cat no: 113302

Supplier: BioLegend
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CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-alpha and LT-alpha (also known as TNF-beta). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-alpha or LT-alpha trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
Catalogue number: 113302
Reactivities: Mouse
Hosts: Hamster
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunoprecipitation
Size: 500 microg
Clone: TR75-54.7
Gene: 21938
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: E. coli -expressed mouse Type II TNFR
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNFRII, TNFR type II, p75, TNFR80, TNFRSF1B
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