LEAF(TM) Purified anti-mouse CD122 (IL-2Rbeta)

Cat no: 123203

Supplier: BioLegend

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CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The TM-beta1 antibody does inhibit IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

Catalogue number:	123203
Reactivities:	Mouse
Hosts:	Rat
Applications:	Block/Neutralize/Inhibit, Flow Cytometry, Immunoprecipitation
Size:	50 microg
Clone:	TM-beta1
Gene:	16185
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	Rat T cell line expressing mouse CD122 ( IL-2Rbeta)
Isotype:	Rat IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	IL-2 Receptor beta chain, IL-2Rbeta, IL-2Rbeta

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LEAF(TM) Purified anti-mouse CD122 (IL-2Rbeta)

Cat no: 123203

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