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LEAF(TM) Purified anti-mouse CD357 (GITR)

LEAF(TM) Purified anti-mouse CD357 (GITR)

Cat no: 126303

Supplier: BioLegend
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GITR glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18,and AITR (in humans).It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells.The expression of GITR on T cells can be upregulated upon activation.Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function ofCD25+CD4+ T reg cells.In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Catalogue number: 126303
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunoprecipitation
Size: 50 microg
Clone: DTA-1
Gene: 21936
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: mouse CD25+CD4+ T cells
Isotype: Rat IgG2b, lambda
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: AITR, TNFRSF18
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