LEAF(TM) Purified anti-mouse CD40

Cat no: 102908

Supplier: BioLegend

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CD40 is a 48 kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39) expressed on activated T cells, is important in costimulation and immune regulation. The HM40-3 antibody has been reported to stimulate dendritic and B cell proliferation and block CD40-CD40L interactions.

Catalogue number:	102908
Reactivities:	Mouse
Hosts:	Hamster
Applications:	Block/Neutralize/Inhibit, Flow Cytometry, Immunohistochemistry
Size:	500 microg
Clone:	HM40-3
Gene:	21939
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	(BALB/c x NZB)F1 mouse-derived lymphoma WEHI 231
Isotype:	Armenian Hamster IgM
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Bp50, TNFRSF5

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LEAF(TM) Purified anti-mouse CD40

Cat no: 102908

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