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LEAF(TM) Purified anti-mouse CD51

LEAF(TM) Purified anti-mouse CD51

Cat no: 104108

Supplier: BioLegend
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CD51 is a 140 kD protein, also known as alphaV integrin, vitronectin receptor, and integrin alphaV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins beta1, beta3, beta5 or beta6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The alphav integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
Catalogue number: 104108
Reactivities: Mouse
Hosts: Rat
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunoprecipitation
Size: 500 microg
Clone: RMV-7
Gene: 16410
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: BALB/c mouse IL-2-activated killer (LAK) cells
Isotype: Rat IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alphaV integrin, Vitronectin Receptor, Integrin alphaV
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